Development and physicochemical characterization of solid lipid nanoparticles containing tinidazole

Background: Periodontitis is a chronic inflammation of the periodontal tissues. To increase effectiveness treatment, antibiotics selected should have spectrum action on bacteria causing periodontitis, while also meeting requirements cell penetration and prolonging retention time at target site. Therefore, this study aimed developing solid lipid nanoparticles (SLNs) containing tinidazole (TNZ-SLNs) oriented to be incorporated into gel ability prolong drug in Objectives: develop characterize Methods: TNZ-SLNs were prepared by combining hot homogenization solvent evaporation using different types lipids surfactants. Factors related formula preparation process investigated, Design Expert 12.0, FormRules v2.0 InForm v3.1 software used design experiments optimize formula. The characterized particle size, polydispersity index (PDI), encapsulation efficiency (EE), etc. Results: optimized formulation had size 197.60 ± 19.67 nm, PDI 0.247 0.011, zeta potential -15.79 0.75mV an EE 37.96 0.91%. showed prolonged vitro release (for up 24 hours), TNZ material achieved about 100% after 4 hours. Conclusion: successfully fabricated physicochemically characterized. Key words: Tinidazole, nanoparticles, periodontitis.